Thursday - December 2, 2021
Feyenoord v Heracles Almelo at 3:00am |
Friday - December 3, 2021
AZ Alkmaar v Fortuna Sittard at 1:45am |
| Ajax v Willem II at 4:00am |
Saturday - December 4, 2021
Groningen v PEC Zwolle at 3:00am |
| PSV Eindhoven v FC Utrecht at 11:30pm |
Sunday - December 5, 2021
Cambuur Leeuwarden v Vitesse Arnhem at 1:45am |
| Heracles Almelo v Heerenveen at 4:00am |
| RKC Waalwijk v NEC Nijmegen at 7:15pm |
| AZ Alkmaar v Sparta Rotterdam at 9:30pm |
| Go Ahead Eagles v FC Twente at 9:30pm |
| Feyenoord v Fortuna Sittard at 11:45pm |
Saturday - December 11, 2021
Willem II v Cambuur Leeuwarden at 3:00am |
Sunday - December 12, 2021
FC Utrecht v Go Ahead Eagles at 1:45am |
| Heerenveen v Sparta Rotterdam at 3:00am |
| PEC Zwolle v Fortuna Sittard at 4:00am |
| FC Twente v RKC Waalwijk at 7:15pm |
| Groningen v Feyenoord at 9:30pm |
| Vitesse Arnhem v Heracles Almelo at 9:30pm |
| Ajax v AZ Alkmaar at 11:45pm |
Monday - December 13, 2021
NEC Nijmegen v PSV Eindhoven at 3:00am |
Saturday - December 18, 2021
Fortuna Sittard v FC Utrecht at 11:30pm |
Sunday - December 19, 2021
Sparta Rotterdam v Vitesse Arnhem at 1:45am |
| AZ Alkmaar v Willem II at 3:00am |
| Heracles Almelo v Groningen at 3:00am |
| PEC Zwolle v FC Twente at 4:00am |
| Cambuur Leeuwarden v Heerenveen at 7:15pm |
| Feyenoord v Ajax at 9:30pm |
| Go Ahead Eagles v NEC Nijmegen at 9:30pm |
| RKC Waalwijk v PSV Eindhoven at 11:45pm |
Wednesday - December 22, 2021
Vitesse Arnhem v PEC Zwolle at 1:45am |
| AZ Alkmaar v Groningen at 4:00am |
Thursday - December 23, 2021
Heerenveen v Feyenoord at 1:45am |
| Willem II v NEC Nijmegen at 1:45am |
| Heracles Almelo v Cambuur Leeuwarden at 3:00am |
| Ajax v Fortuna Sittard at 4:00am |
| FC Utrecht v FC Twente at 4:00am |
