Wednesday - September 22, 2021
Fortuna Sittard v Ajax at 12:45am |
| RKC Waalwijk v Willem II at 3:00am |
Thursday - September 23, 2021
Go Ahead Eagles v PSV Eindhoven at 12:45am |
| NEC Nijmegen v FC Utrecht at 12:45am |
| Groningen v Vitesse Arnhem at 2:00am |
| Feyenoord v Heerenveen at 3:00am |
| PEC Zwolle v Sparta Rotterdam at 3:00am |
Friday - September 24, 2021
Cambuur Leeuwarden v Heracles Almelo at 12:45am |
| FC Twente v AZ Alkmaar at 3:00am |
Saturday - September 25, 2021
Willem II v PSV Eindhoven at 10:30pm |
Sunday - September 26, 2021
Ajax v Groningen at 12:45am |
| Vitesse Arnhem v Fortuna Sittard at 12:45am |
| FC Utrecht v PEC Zwolle at 3:00am |
| Feyenoord v NEC Nijmegen at 3:00am |
| Sparta Rotterdam v Cambuur Leeuwarden at 6:15pm |
| AZ Alkmaar v Go Ahead Eagles at 8:30pm |
| Heerenveen v FC Twente at 8:30pm |
| Heracles Almelo v RKC Waalwijk at 10:45pm |
Saturday - October 2, 2021
Groningen v FC Twente at 2:00am |
Sunday - October 3, 2021
RKC Waalwijk v Go Ahead Eagles at 12:45am |
| Heracles Almelo v Willem II at 2:00am |
| PEC Zwolle v Heerenveen at 2:00am |
| Fortuna Sittard v NEC Nijmegen at 3:00am |
| Ajax v FC Utrecht at 8:30pm |
| Cambuur Leeuwarden v AZ Alkmaar at 8:30pm |
| Vitesse Arnhem v Feyenoord at 10:45pm |
Monday - October 4, 2021
PSV Eindhoven v Sparta Rotterdam at 2:00am |
